Genetic Mutations and its Latency in ADHD Patients

Medgenics, MDGN, – a company dedicated to genomic research and developing new methods of therapies for people with ‘life-altering diseases’ has acquired data that suggests that ADHD patients have mutated genes.

Genetic mutations in ADHD
Genetic mutations in ADHD victims has been an ongoing discussion among scientific communities

The study, presented in AACAP’s 63rd annual meeting in New York  was led by Dr. Josephine Elia, Neuroscience Centre,  Department of Child and Adolescent Psychiatry, was about the role of  glutamate neurotransmission in Neuropsychiatric disorders.

A similar suggestion was made by Italian researcher Maria Nobile, MD, PhD, Child Psychopathology Unit, Scientific Institute, IRCCS who suggested that persistent ADHD might be genetic.

After a careful analysis of the data acquired from studying 1013 children, it was found that Dr Elia was correct in her earlier observation in 2010.

The research underscored the criticality of mGlur, or commonly referred to as glutamate receptors in disorders such as ADHD.

Glutamate is a form of neurotransmitter and Glutamate Receptors modulate synaptic plasticity, which are extremely important for brain functions such as learning and memory.

Mutated receptors can have permanent effects on functionings of brain, which is the key cause behind a number of neuro-developmental disorders.

Dr Elia further commented that the study suggested the very important fact. It showcased that mutations exist which can well disable these genes which has an association with ADHD.

These mutations were found to be present in as much as 25 % children diagnosed with ADHD.

The frequency of mutation was pinned to be almost 22%. Among chilled aged 6-12 years, it was as high as 25%.

Individuals with mutated glutamate receptors were observed to have more issues when it came to disruptive behaviors and anger control management.

Currently, Medgenics is focusing on an intensive research aimed at better understanding the relatively high severity of Attention Deficit Hyperactive Disorder among individuals with network mutations.

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